Fabrication and Characterization of a Gelatin-based Hydrogel Incorporating Mesoporous Bioactive Glass Nanoparticles for Tissue Regeneration

In recent decades, tissue engineering has demonstrated significant potential for regenerating damaged tissues. Hydrogel scaffolds have gained particular importance as they mimic the extracellular matrix (ECM) and create an optimal environment for cell survival and proliferation. Developing multifunctional bioactive hydrogels with tunable physical and biological properties is crucial for advancing tissue engineering applications. Mesoporous bioactive glass nanoparticles (MBGNs) have attracted considerable interest because of their excellent textural properties and ability to release biologically active ions beneficial for regenerating various tissues, including bone and skin. The release of silicon and calcium ions from MBGNs has been shown to promote skin regeneration by stimulating collagen production and enhancing neovascularization. Incorporating MBGNs into hydrogels enhances bioactivity and significantly affects their physical and mechanical properties, enabling the creation of bioactive and tunable hydrogels for tissue regeneration. This study developed an enzymatically cross-linked nanocomposite hydrogel using gelatin-tyramine and MBGNs as a novel scaffold for skin regeneration, aiming to evaluate how different MBGN concentrations affect the hydrogel's physical and biological properties.

کلیدواژه ها:

Tissue engineering ، Hydrogel scaffolds ، Mesoporous bioactive glass nanoparticles ، MBGNs ، Skin regeneration