The Impact of an Open-label Design on Human Amniotic Membranes vs. Silver Sulfadiazine Dressings for Second-degree Burns: A Randomized Controlled Clinical Trial

Background Burn wounds require optimal medical management due to associated psycho-emotional and socioeconomic impacts, and severe pain. Utilizing synthetic and biological dressings improves healing and reduces burn wound complications. The present study aimed to compare the outcomes of using a human amniotic membrane (HAM) and conventional silver sulfadiazine (SSDZ) ointment as the dressings, in the management of the second-degree burn wound, ۲۰۱۸, Zanjan, Iran. Methods Fifty patients participated in this clinical trial and were divided into two groups by simple randomization. The target group (n = ۲۵) was treated with HAM, and the control group (n = ۲۵) was treated with the SSDZ ointment. The researcher-designed checklist was used to determine the clinical performance in the follow-up assessments on days ۷, ۱۴, and ۳۰. Results No significant difference was found in terms of gender, age, and the percentage of the burn wound (P > ۰.۰۵). Wound epithelialization (days ۷, ۱۴, and ۳۰), scar and pigmentation of the wound, pain severity, the amount of analgesia required, and the hospital stay length (on day ۳۰) were significantly less in the target group, compared to the control (P

کلیدواژه ها:

Burns ، Amniotic Membrane ، Silver Sulfadiazine ، clinical trial