Investigating the Effect of Hemoperfusion Therapy on Laboratory and Clinical Factors in COVID-۱۹ Patients: A Cross-Sectional Study

Background: With the epidemic of the emerging COVID-۱۹ disease in the world in ۲۰۱۹ and the lack of a definitive and effective treatment for it, medical science practically faced a new challenge, this study aimed to investigation the effect of hemoperfusion therapy on laboratory and clinical factors in COVID-۱۹ patients. Materials & Methods: In this cross-sectional study, ۴۹ patients with severe COVID-۱۹, who had indications for hemoperfusion were examined in ۲۰۲۰-۲۰۲۱. The patients underwent four hemoperfusion sessions after inserting a vascular catheter and preparing a special filter. Changes in laboratory and clinical factors before and after each hemoperfusion session were carefully recorded, and the data were analyzed using SPSS software. Findings: The results of the study showed that the average age of the patients was ۵۵.۵ ± ۱۳.۹ years. Changes in the patients’ blood oxygen saturation levels after each hemoperfusion session showed a statistically significant improvement trend, the average values before and after the first session were ۸۶.۷±۷.۲% and ۸۸.۵±۵.۷%, respectively, indicating a significant increase (p= .۰۰۹). Also, the inflammatory factor CRP (C-reactive protein) and blood platelet levels were significantly reduced after each hemoperfusion session. Conclusion: This study showed that hemoperfusion could improve patients’ blood oxygen saturation values without causing any special complications and could also have a clear effect on clearing inflammatory factors and CRP from the blood.

کلیدواژه ها:

Hemoperfusion ، COVID-۱۹ ، Clinical factors