Prognostic Significance of lncRNA ATB and SNHG۱۶ Expression Levels in Patients with Hepatocellular Carcinoma

Background & Objective: Long noncoding RNAs (lncRNAs) are transcripts longer than ۲۰۰ nucleotides, a major component of noncoding RNAs. Previous studies have shown the oncogenic role of various lncRNAs. This study aimed to explore the expression and prognostic value of ATB and SNHG۱۶ in patients with hepatocellular carcinoma.Methods: ATB and SNHG۱۶ expression in tumor and adjacent normal tissues was identified using real-time quantitative PCR. In this study, patients were divided into ۲ groups based on the expression level of each gene, and the correlation between expression level and clinicopathological features of patients with HCC was investigated. All data were analyzed using SPSS version ۲۲.Results: Of the lncRNAs examined in this study, ATB was expressed at significantly higher levels in tumor tissues. However, this overexpression was not associated with any clinicopathological features of HCC patients.Conclusion: In this study, overexpression of ATB and SNHG۱۶ was not associated with survival rate or clinicopathological features of patients with hepatocellular carcinoma.

کلیدواژه ها:

Hepatocellular Carcinoma ، Long Noncoding RNAs ، Tumor