Bioinformatics Analysis of Peroxisomal Biogenesis Factor Proteins in Breast Malignancy for Introducing Potential Prognostic Biomarkers

Background & Objective: Breast cancer (BC) is the most common type of malignant neoplasm and is the primary cause of mortality among women aged ۴۵ to ۵۵ years. Studies indicate that cancer displays irregular metabolic patterns in contrast to normal tissue. Furthermore, there is compelling evidence supporting the significant role of peroxisomes in the intricate metabolic processes of cancer. Peroxisomal biogenesis factors (PEXs), which are peroxisomal proteins, control activities such as the degradation and biogenesis of peroxisomes. Hence, the correlation between peroxisomal biogenesis factor expression and BC was explored, to introduce key proteins and potential biomarkers by analyzing.Methods: This study utilized UALCAN, GenExMiner v۴.۸, Metascape, STRING, TIMER, the Kaplan-Meier plotter, The Human Protein Atlas, MirTarBase, and cBioportal.Results: The transcriptional levels of PEX۶/۷/۱۰/۱۱B/۱۳/۱۶ in BC tissues were significantly elevated, whereas the transcriptional levels of PEX۲/۳/۵/۱۱A/۱۲/۱۹ were significantly reduced. High expression levels of PEX ۲/۳/۱۰/۱۲/۱۱G /۲۶/۱۳/۱۶/۱۴ were significantly related to shorter relapse-free survival, and higher mRNA expression of PEX ۱۱B/۱۱G/۱۱A/۱۲/۱۹ was significantly associated with longer overall survival of BC patients. We identified has-miR-۴۳۱۸ and has-۷۱۰۶-۳p as more correlated miRNAs with the PEX family.Conclusion: Our results may provide novel insights for the selection of therapeutic targets and prognostic biomarkers for BC.

کلیدواژه ها:

Peroxine ، breast tumor ، prognostic marker