pH-Responsive Mesoporous Silica Nanoparticles Functionalized with Biocompatible Polymers for Targeted Drug Delivery

A pH-responsive drug delivery system was developed using mesoporous silica nanoparticles (MSN) functionalized with poly(acrylic acid) (PAA) and poly(۲-hydroxyethyl methacrylate) (pHEMA). MSN were synthesized via the sol-gel method and modified through radical polymerization to enhance biocompatibility, pH responsiveness, and drug release properties. Fourier Transform Infrared (FTIR) spectroscopy confirmed functional group incorporation, while Scanning Electron Microscopy (SEM) revealed morphological changes post-functionalization. This study demonstrates the potential of functionalized MSN for targeted and controlled drug delivery, particularly in chemotherapy, by improving drug release efficiency and reducing side effects.

کلیدواژه ها:

Mesoporous silica ، pH-responsive ، poly(acrylic acid) ، poly(۲-hydroxyethyl methacrylate) ، Drug Delivery