Efficient synthesis of ۲-amino-۳-cyanopyridines using functionalized silica-coated magnetite nanoparticles with Cu(I)-thiosemicarbazone complex (Fe۳O۴@SiO۲-[CuL])

The synthesis, characterization, and application of functionalized silica-coated magnetite nanoparticles with Cu(I)-thiosemicarbazone complex (Fe۳O۴@SiO۲-[CuL]) for synthesis of ۲-amino-۳-cyanopyridines is described. The four-component reaction of ketones, ammonium acetate, malononitrile, and aldehydes using Fe۳O۴@SiO۲-[CuL] in refluxing H۲O/EtOH affords ۲-amino-۳-cyanopyridines in high yields. The catalyst could be easily separated by a simple magnet and reused for at least ۷ runs.

کلیدواژه ها:

۲-amino-۳-cyanopyridines ، Fe۳O۴@SiO۲-[CuL] ، four-component reaction ، heterogeneous nano catalyst