Exploring Different Approaches for Stabilizing DNA Polymerase on Graphene: Voltage Reduction as a Measurement Criterion

DNA sequencing is essential for identifying genetic traits, diagnosing diseases, and finding mutations relevant to treatment and drug development. Nanopore sequencing is effective for long biopolymers like DNA, RNA, and proteins. Graphene nanopores improve sequencing due to their superior electrical, mechanical, and thermal properties, though rapid DNA translocation can hinder nucleotide detection accuracy. Phi۲۹ DNA polymerase increases sequencing accuracy by slowing DNA movement through graphene nanopores. Its use in graphene nanopores represents a promising advancement in biosensing, leveraging the advantages of both graphene and the enzyme.

کلیدواژه ها:

DNA sequencing ، nanopore sequencing ، graphene nanopores ، DNA polymerase ، molecular dynamics simulations