Recent advances and challenges in diabetes therapy by non-viral and viral gene carriers: A review

Recent progress in diabetes therapy using viral gene carriers has shown great attention but also faces remarkable clinical limitations. The applications of viral vectors to deliver therapeutic genes for diabetes treatment may improve insulin production and modulation of immune responses. In the case of gene therapy for diabetes, the promising approach is the application of viral vectors including adenoviruses, lentiviruses, or adeno-associated viruses (AAVs) to deliver specific genes that either regenerate or increase the function of insulin-producing beta cells in the pancreas. Some investigations are applying these viral vectors for the delivery of genes encoding insulin or transcription factors that promote the differentiation of stem cells into insulin-producing cells. Therefore, this review has tried to address recent advances and the clinical challenges faced in viral gene therapy for diabetes.

کلیدواژه ها:

Diabetes ، Adenoviruses ، Lentiviruses ، Adeno-associated viruses ، Beta cells