Anticancer and tissue engineering applications of polyester polymers: A critical mini-review

Polyester polymers are abundantly studied and employed in a variety of biomedical aspects, specifically tissue engineering and anticancer therapy. The main therapeutic benefits of polyester polymers are biocompatibility and the ability to be easily functionalized and modified for specific applications. In the case of tissue engineering, the controlled degradation of polyester scaffolds can be possible by using polyester polymers. For instance, scaffolds composed of poly(glycerol sebacate) (PGS)-polycaprolactone (PCL)-gelatin possess strong mechanical properties and strong potential for application in cartilage regeneration and heart valve replacements. By suitable engineering of three-dimensional (۳D) scaffolds, these polymers are gradually degraded without causing allergic and inflammatory reactions by their toxic byproducts. In addition, these polymers have shown promising applications in the production of drug delivery systems (DDS) for various types of cancers. In this mini-review, authors have explored recent progress and challenges regarding applications of main polyester polymers in tissue engineering and cancers.

کلیدواژه ها:

Polyesters ، ۳D scaffolds ، Inflammatory reactions ، Drug delivery systems