Current approaches for tissue engineering and anticancer applications of polyether polymers: A review

There is an emerging necessity for designing novel ۳D scaffolds and drug delivery systems (DDSs) to address the clinical limitations of conventional scaffolds and chemotherapy. Numerous biomaterials, particularly polyether polymers with desirable biocompatibility and biodegradability have been explored to produce ۳D scaffolds for various tissues including bone, cartilage, and cardiovascular tissues. Furthermore, polyether polymers such as polyethylene glycol (PEG), polypropylene oxide (PPO), and poly(tetramethylene oxide) or polytetrahydrofuran (PTHF) have been utilized to fabricate micro and nanoformulations of anticancer drugs and compounds for bypassing severe side effects and multidrug resistance of chemotherapeutic drugs and cancer cells, respectively. However, there are still several clinical hindrances to achieving optimum outcomes in both tissue engineering and cancer therapy. In this regard, the present review delved into the novel formulations of polyether polymers to obtain maximum results in tissue engineering and cancer therapy.

کلیدواژه ها:

۳D scaffolds ، Drug delivery system ، Clinical limitations ، Cardiovascular Tissue ، Polymer structures