Side Effects of Rituximab in Patients with Multiple Sclerosis

Background: Multiple Sclerosis (MS) is the most common demyelinating inflammatory disease of the central nervous system. Rituximab is an anti-CD۲۰ monoclonal antibody used as a primary drug for MS; however, it can cause injection and post-consumption side effects. Objectives: This study aimed to determine the side effects of rituximab in patients with Multiple Sclerosis. Methods: This descriptive-analytical study focused on MS patients who had received Rituximab and regularly visited Isfahan Multiple Sclerosis clinics in ۲۰۲۱. These patients had received at least two doses of Rituximab (۱۰۰۰ mg), and their symptoms and examinations were documented during face-to-face visits using checklists. The data were analyzed using SPSS version ۲۲. Results: In this study, ۱۵۰ patients with MS participated. The number of attacks (more than one) before and after using Rituximab was ۲۲% and ۴.۷%, respectively. The mean EDSS score among them before and after Rituximab was ۳.۵۳ ± ۱.۳۰ and ۳.۶۶ ± ۱.۵۱. ۶۸.۷% of the patients showed infusion side effects, such as a sore throat and dyspnea. Moreover, post-consumption side effects included muscle spasm, weight gain, arthralgia, and edema of the extremities. Conclusion: The mean EDSS score before and after using Rituximab showed a slight increase, indicating no significant effects on improving dysfunctions, but the attack rate was reduced.

کلیدواژه ها:

Multiple Sclerosis ، Rituximab ، Side Effects