Evaluation of Anti-psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-like Dermatitis in Mice

Background: One of the most significant Sudanese medicinal plants is Aloe sinkatana, which has considerable pharmacological activity and has been historically used to treat psoriasis and other skin conditions. Objectives: This study aims to evaluate the A. sinkatana plant’s anti-psoriatic properties. Methods: The imiquimod (IMQ)-induced psoriasis mice model was used to evaluate the anti-psoriatic effect of the A. sinkatana plant. So, the effects of ۰.۱% and ۰.۲% extracts of A. sinkatana extract on five groups of mice were assessed and compared with the conventional medication, i.e. dexamethasone. Differences between treatment groups were evaluated by a one-way analysis of variance, followed by a post hoc Fisher least significant difference test using the SPSS software, version ۲۰. At P<۰.۰۵, differences were deemed significant. A minimum of three replicates were used in each duplicate experiment. For all values, Mean±SD was used.  Results: The extracts showed a significant and remarkably strong anti-psoriatic effect since the percentages of psoriasis-like symptoms were reduced in groups treated with ۰.۲% Aloe extract (A.E), ۰.۱% A.E, and dexamethasone ۸۶%, ۸۴%, and ۶۸%, respectively. Both extract concentrations improved the psoriatic lesions and decreased the grading of the treated groups’ psoriasis area and severity index (PASI) scale. Conclusion: Due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by A. sinkatana extract. This herb may be beneficial in the pharmaceutical formulation of new safe and effective medication for treating psoriasis.

کلیدواژه ها:

Aloe sinkatana ، Dermatitis ، Extracts ، Imiquimod (IMQ) ، Psoriasis area and severity index (PASI) ، Mice