Prognostic Value of Magnetic Resonance Spectroscopy in Patients With Diffuse Axonal Injury: Systematic Review Of The Literature

Introduction: Magnetic resonance spectroscopy (MRS) is an imaging technique that provides spectroscopic information on the changes in biological markers. Studies suggest that MRS can be valuable in the prognosis of patients with diffuse axonal injury (DAI).Methods: PubMed and Scopus, two major databases, were systematically searched in June ۲۰۱۵ using the following search strategy: ((((Magnetic resonance spectroscopy OR MRS OR MR spectroscopy)) AND (Diffuse axonal injury OR DAI)) AND Prognosis). Relevant articles were selected, and the prognostic value of MRS in patients with traumatic DAI was investigated. All necessary information was extracted for data synthesis based on the primary objective of this study.Results: Out of ۱۹ articles found in PubMed and ۱۵۱ in Scopus, eight documents were selected for data extraction following inclusion/exclusion criteria. The total number of patients included in the selected studies was ۱۹۷. All selected articles demonstrated that MRS can be used to quantitatively analyze metabolite changes in patients with DAI.Conclusion: Based on the results of the included studies, MRS is a sensitive tool that can help predict the prognosis of patients with DAI.