Decoding biofilm-driven antibiotic resistance in uropathogens: Clinical and regional insights

Urinary tract infections (UTIs) caused by biofilm-producing uropathogens present a major challenge in antimicrobial resistance management. This study investigated the biofilm formation and antibiotic susceptibility of uropathogens isolated from patients at IRH. One hundred sixty-eight mid-stream urine samples were analyzed, yielding ۱۵۲ pathogens, predominantly Staphylococcus aureus (۴۴.۰۸%) and Escherichia coli (۲۶.۳۲%). Biofilm formation was confirmed in ۲۳ isolates (۱۵.۱۳% of total pathogens, ۱۳.۷% of total samples) Percentage explicitly mentioned. (۱۵.۱۳% of total pathogens) using the Congo red agar (CRA) method, highlighting biofilm as a critical virulence factor. The study focused on biofilm-positive isolates; the highest inhibitory zones were observed for augmentin (۳۴ mm), ciprofloxacin (۳۲ mm), and meropenem (۳۰ mm), whereas Klebsiella pneumoniae exhibited total resistance. Women aged ۳۱–۴۰ years were most affected, emphasizing gender-specific vulnerability. However, future studies should include antibiograms for all isolates, including non-biofilm formers, to provide a more comprehensive understanding of resistance patterns.

کلیدواژه ها:

Biofilm-Associated Infections ، Antibiotic Resistance ، Uropathogenic bacteria ، Urinary tract infections ، Antimicrobial Susceptibility Patterns