Superoxide Dismutase Inhibitors as Cancer Chemopreventive Agents: A New Survey

Reactive oxygen species (ROS) are important factors to carcinogenesis, serving as both initiators and promoters of tumor growth. Superoxide dismutases (SODs), a kind of antioxidant enzyme, regulate ROS levels by converting superoxide anions into hydrogen peroxide. While SODs have generally served protective roles, current research has revealed a paradoxical involvement in cancer cell survival and resistance to treatment. This review presents a complete overview of current understanding about SOD inhibitors and their potential as cancer chemopreventive medicines, with a focus on processes, molecular targets, and treatment methods. Eighteen references are mentioned to lay a solid basis for future study in this promising field of cancer.

کلیدواژه ها:

Reactive Oxygen Species (ROS) ، Superoxide Dismutases ، Protective Roles ، Cancer cell survival ، Cancer Chemopreventive