Drug repurposing for brain cancer

Health and wellbeing are a crucial component for quality of society and life, one of the worries is cancer. Brain cancer has a highly negative emotional toll on patients and caregivers, the patient may lose their productivity and it has huge costs. Brain tumors can start in the brain or cancer can spread to the brain from other parts of the body and tumor treatment options depend on the type of brain tumor you have, as well as its size and location. Common treatments include surgery and radiation therapy. Drug repurposing is a way to re-use well-known drugs to control the undesirable genes expressed and as an immunological treatment, it helps the immune system to beat the cancer. We chose a database on GEO and compared with significant genes on CoreMine using two statistical conditions, p-value and |log FC|, there are ۸۶۹ genes remain of over ۱۶۰۰۰. Then we used STRING to find PPI network, now we have the PPI network of the most important genes according to two databases. In this step we made a ۵-cluster graph out if the PPI network and sorted the genes by node degree, then we picked ۱۰ higher degree genes as hub genes. Using DGIdb database, we chose the effective drugs on these ۱۰ hub genes and picked the approved by FDA. Then sort them by interaction score and made a list of hub genes and drugs. We considered the side effects of these drugs using Drug Bank database. The final result is the effective drugs with considering side effects that potentially can be used as a treatment for brain cancer, namely: CINNARIZINE, CLOFIBRATE, ZANUBRUTINIB, AFATINIB, OBINUTUZUMAB, TRIFLURIDINE, PIRTOBRUTINIB, MOBOCERTINIB, DACOMITINIB ANHYDROUS.

کلیدواژه ها:

brain cancer ، network-based analysis ، drug repurpose ، hub genes ، PPI Network