Recent Advances in Dengue Fever Based on Serotypes, Virulence Factors, Prevention, and Treatment: A Comprehensive Review

Dengue fever, a Flaviviridae viral disease, exhibits various clinical symptoms, such as hemorrhagic fever, and is influenced by multiple factors. This comprehensive review aims to explore different aspects of dengue fever. The morbidity of the virus is affected by its serotype, which has three structural proteins (capsid, pre-membrane, and envelope), seven nonstructural proteins, and the host’s immune system. Neutralizing antibodies are highly recommended to stop the virus replication. The most effective way to prevent the virus is to eliminate or reduce human interaction with its carriers; "Dengvaxia", a tetravalent vaccine, is also approved.