Green Synthesis of New Triazoloquinazolines Employing Cu/Fe₃O₄@MWCNT MNCs: Investigation of Biological Activity

We applied the Petasites hybridus rhizome water extract as green media so that the Cu/Fe۳O۴@MWCNT MNCs could be prepared. We also evaluated its activity by using in the one-pot multicomponent reaction of isatoic anhydride, ammonium acetate, activated acetylenic compounds, alkyl bromide and hydrazonoyl chlorides in aqueous medium at room temperature for the generation of pyrrolo [۱,۲,۴]triazoloquinazoline as new derivatives with tremendous output. Besides, reducing organic pollutants of the ۴-nitrophenol (۴-NP) was carried out by generating Cu/Fe۳O۴@MWCNT MNCs in water at room temperature. The results displayed the Cu/Fe۳O۴@MWCNT MNCs reduced pollutants of organic compounds in a short time. The synthesized pyrrolo [۱,۲,۴]triazoloquinazoline have high antioxidant power. Also, the pyrrolo [۱,۲,۴]triazoloquinazoline exhibited antimicrobial ability. For this purpose, the disk diffusion method was applied and two kinds of bacteria Gram-positive and Gram-negative were employed for the analysis. To generate pyrrolo [۱,۲,۴]triazoloquinazoline, the applied process showed many properties such as reactions with short time, product with good yields, simple extraction of catalyst from mixture of reaction.

کلیدواژه ها:

Cu/Fe₃O₄@MWCNT ، Pyrrolo [۱ ، ۲ ، ۴]triazoloquinazoline ، Antioxidant activity ، Isatoic anhydride ، Ammonium acetate ، Activated acetylenic compounds