Overview of Bacteria and Surfactins as Anticancer Agents

Cancer is one of the deadliest diseases worldwide. Late diagnosis of this disease leads to high mortality rates. Conventional treatments such as chemotherapy and radiation therapy have low survival rates. Bacteria are utilized in various ways in cancer treatment, primarily through their antitumor effects. Surfactins are recognized as anticancer agents; these surfactins are cyclic lipopeptides isolated from various Bacillus strains. The cytotoxic activities of surfactins against human chronic myelogenous leukemia cells, human colorectal cancer cells, and liver cancer cells are well-documented. Surfactins are targeted to cancer cells via nanocarriers or nanoformulations. The biosynthesis of surfactins is regulated by surfactin synthetase enzymes. These results position bacterial therapy as a promising treatment for cancer.Cancer is one of the deadliest diseases worldwide. Late diagnosis of this disease leads to high mortality rates. Conventional treatments such as chemotherapy and radiation therapy have low survival rates. Bacteria are utilized in various ways in cancer treatment, primarily through their antitumor effects. Surfactins are recognized as anticancer agents; these surfactins are cyclic lipopeptides isolated from various Bacillus strains. The cytotoxic activities of surfactins against human chronic myelogenous leukemia cells, human colorectal cancer cells, and liver cancer cells are well-documented. Surfactins are targeted to cancer cells via nanocarriers or nanoformulations. The biosynthesis of surfactins is regulated by surfactin synthetase enzymes. These results position bacterial therapy as a promising treatment for cancer.

کلیدواژه ها:

Bacteria ، Treatment ، Cancer ، Tumor ، Surfactin.