The role in Regulatory of G proteins signaling (RGS) proteins in brain excitability

Heterotrimeric G proteins involved in many transmembrane signaling in the nervous system. Regulation of the signaling speed of G proteins is done by different types of proteins. One of the most important types of these proteins are called, Regulatory of G proteins signaling Proteins (RGS), that increase the GTPase activity of Ga subunit of  G proteins. These proteins have more than ۳۰ members and are characterized by the existence of a region of ۱۲۰ amino acids, which is called the RGS region Today, it has been determined in addition to increase GTPase activity, RGS proteins can also act as antagonists of effectors by competing with effector molecules to bind to active Gα Another is RGS proteins specifically and selectively regulate the function of receptors coupled to G proteins and ion channels and other signaling events. The RGS protein family has essential roles in GPCR signaling in the nervous system. At neuronal synapses, GPCRs, G proteins, and RGS proteins work with together to regulate key aspects of neurotransmitter release, synaptic transmission, and synaptic plasticity that are necessary for CNS physiology and behavior thereby affecting neuronal excitability in the central nervous system. Studies have shown that the levels of cAMP and protein kinase A in the brain of seizure patients are more different than those of healthy subjects that this mediated by G proteins signaling.

کلیدواژه ها:

G-proteins ، RGS proteins ، Seizure ، Brain excitability