Intensity-dependent effects of mild electric foot stimulation on seizures in chemical kindling model in rats

Introduction Epilepsy is a common neurological disorder that affects millions of people worldwide. While there are many treatment options available, including drug and non-drug therapies, there is still a need for effective treatments that can help manage seizures.The present study aimed to investigate the intensity-dependent effects of mild electric foot stimulation on seizure intensity following pentylenetetrazol (PTZ)chemical kindling in rats. Methods: Kindled seizures were induced in rats by repeated injections of PTZ. Twenty-seven male rats were randomly divided into three groups: kindling group, kindling group + ۰.۱ mA electrical stimulation, and kindling group + ۰.۰۱ mA electrical stimulation. Electrical stimulation was induced using an electric box equipped with steel rods following acquisition of kindled seizures. The intensity of the mild electric foot stimulation was either ۰.۱ or ۰.۰۱ mA depending on the tested group. Results: The study found that while mild electric foot stimulation with intensity of ۰. ۱ mA had proconvulsive effects on PTZ-induced kindled rats, and decreased the latency to the onset of stage ۵ seizure (p<۰.۰۵), stimulation with intensity of ۰.۰۱ mA did not have significant effects on seizure parameters. Conclusion: Obtained results suggested that mild electric foot stimulation may have anticonvulsant effects, but only at certain intensity. This finding has important implications for future research into the use of mild electric foot stimulation as a treatment for epilepsy.

کلیدواژه ها:

Kindling ، Epilepsy ، Pentylenetetrazole ، Electrical stimulation