The effect of endurance, resistance and concurrent exercise with oral consumption hawthorn extract in some inflammatory biomarkers in induced Alzheimer's male rats

Introduction: endurance and resistance exercise and the consumption of hawthorn alone and in combination have an effect on Alzheimer's disease.This study was conducted with the aim of the effect of hawthorn consumption and exercise on the inflammatory indices of Alzheimer's rats by trimethyltin chloride (TMT). Materials and methods: rats were randomly divided into ۹ healthy control and Alzheimer's groups with interventions (control, endurance training, resistance training, combined training, hawthorn, endurance training + hawthorn, resistance training + hawthorn, combined training + hawthorn). Then Alzheimer's disease developed. performed resistance , combined ,endurance exercises every week (۱۲ weeks). Finally, blood was taken from the inferior vena and the inflammatory variables CRP, IL-۶ ,TNF-α were measured by ELISA method. The Shapiro-Wilk test was used to check the normal distribution of the data, and the one-way analysis of variance (ANOVA) was used to check the mean difference between the groups (Tukey's test). P ​​<۰.۰۵ were considered statistically significant. Results: results showed that the induction of Alzheimer's disease induced by TMT caused a significant increase in the levels of TNF α, IL ۶, CRP in the Alzheimer's control group compared to the healthy control. And ۱۲ weeks of combined training with and without hawthorn had a significant decrease in the level of these variables compared to Alzheimer's control. Conclusion: As a result, endurance and resistance sports along with the consumption of hawthorn lead to the reduction of some inflammatory factors in Alzheimer's rats.  key words: Alzheimer Disease, Hawthorn TNF-α , CRP ,  IL-۶ .

کلیدواژه ها:

Hawthorn ، Alzheimer Disease ، TNF-α ، CRP ، IL-۶