Comparison the effects of hydroalcoholic extraction of Hyssopus officinalis L with diazepam on epilepsy in chemical kindling induced by PTZ.

Background and Objective: Epilepsy is one of the most complex neurological disease.   Despite existence of synthetics drugs for epilepsy, some patients suffer from side effects of available medicine and unresponsiveness of seizures.  Use of traditional herbal medicine for treatment of disease is proposed as a therapeutic modality.  In attention to components of Hyssopus officinalis L and use of it in folk medicine, the aim of this investigation was to study of the anti-convulsive effects of Hyssopus officinalis L extract on epilepsy Material and methods: In this experimental study ۵۶ adult male mice divided into ۷ groups (n=۸) including: ۱-control group receiving only Pentylenetetrazole (PTZ), ۲- sham group receiving distilled water and ۵ experimental groups that ۳۰ minutes before PTZ injection received   hyssopus by gavages in doses of ۱۰۰, ۲۰۰, ۴۰۰ and ۸۰۰ mg/kg of body weight and diazepam by injection in doses of ۲ mg/kg.  Kindling was achieved by ۱۲times intraperitoneal injection of ۴۵ mg/kg of body weight of PTZ at every ۴۸ hours. Results: Data analysis indicated that treatment with hyssopus has a significant effect on chemical kindling that comparable with diazepam. It decreases progress of seizure phases considerably (P˂۰.۰۵) and increases latency time of seizure significantly (P˂۰.۰۵) but don’t has significant effect on seizure duration. Conclusion: The results shows extract of Hyssopus officinalis L has anticonvulsant effect on PTZ kindling. Thus, it may to be beneficial for seizure treatment

کلیدواژه ها:

Epilepsy ، kindling ، Pentylenetetrazole ، Hyssopus officinalis L. ، صرع- کیندلینگ- پنتیلن تترازول- زوفا