Can resisted swimming exercise substitute for the protective effects of estrogen on cardiometabolic risk factors in obese postmenopausal rat model?

Objective(s): Following our previous studies on the anti-obesity and cardioprotective effects of ۱۷-beta estradiol (E۲), this study was designed to determine the effects of Resisted swimming (RSW) training and E۲ (alone and in combination) on cardiometabolic risk factors in an obese postmenopausal rat model.Materials and Methods: Female ovariectomized rats (OVX) were given a standard diet (SD) or a ۶۰% high-fat diet (HFD) for ۱۶ weeks and were divided into two groups:  SD and HFD. The rats were divided into ten groups to assess the effects of ۸ weeks of E۲ (۱ mg/kg, IP) administration and RSW (۵ days a week) on cardiometabolic risk factors. Parameters including body weight, BMI, visceral fat, blood glucose (BG), and cardiac oxidative stress were assessed ۷۲ hr after the last swimming session.Results: HFD increased body weight, BMI, visceral fat, and BG levels in OVX rats. Additionally, it negatively affected the lipid profile and cardiac oxidative stress, but both E۲ and RSW reduced these parameters in HFD-fed OVX rats. Although RSW and E۲ equally prevented these changes, swimming was more effective than estrogen in increasing HDL levels in the SD group. The combination of E۲ and RSW had a more significant effect on modulating glucose, TAC, TG, and HDL indices than the individual treatments.  Conclusion: Overall, RSW ameliorates cardiometabolic risk factors in postmenopausal conditions caused by obesity, probably by modulating cardiac oxidative stress. It is also an effective non-pharmacological treatment for E۲ substitution.

کلیدواژه ها:

۱۷ beta-estradiol ، Bilateral ovariectomies ، High-fat diet ، Oxidative stress ، Swimming