Microbial Etiology and Antibiotic Susceptibility of Samples from Neonatal Intensive Care Units Patients in a Tertiary Care Center in Iran

Background: Bacterial infection among neonatal patients admitted to the neonatal intensive care unit (NICU) is a global crisis and is among the first causes of neonatal mortality globally. Hence, this study aimed to evaluate the prevalence of bacterial pathogens from collected samples of neonatal infection in the NICU of a tertiary care center in Tehran, Iran. Methods: In this study, we used data from blood, ulcer/fluids, and urine samples of NICU neonates at Imam Khomeini Hospital from ۲۰۱۹ to ۲۰۲۲. Results: Overall, ۷۱۲ urine cultures (۱۴۴ positives), ۴۵۷۸ blood cultures (۳۷۶ positives), and ۱۷۷۱ ulcer/fluid cultures (۴۱۱ positives) were gathered. Among positive blood cultures, the most prevalent bacterial species was Klebsiella pneumonia (۱۲۰, ۳۲.۸۸%). Among urine cultures, the most prevalent bacterial species was Klebsiella pneumonia (۷۱, ۴۹.۳۱%). Among positive ulcer/fluid cultures, the most prevalent bacterial species were Coagulase Negative Staphylococci (۱۵۰, ۳۶.۴۹%). The highest sensitivity of Klebsiella pneumonia was against Ciprofloxacin (۱۵.۸۳%) in blood samples and resistant to Gentamycin (۸۱.۶۷%). Among urine samples, the highest sensitivity of Klebsiella pneumonia was against Ciprofloxacin (۲۹.۵۸%%) and the highest resistance against Gentamycin (۸۴.۵۱%). Among the ulcer/fluid samples, the highest sensitivity of Coagulase Negative Staphylococci was against Ciprofloxacin (۱۳.۴۸%) and the highest resistance against Cotrimoxazole (۱۴.۸۱%). Conclusion: The most prevalent bacterial species found were Klebsiella pneumonia and Coagulase Negative Staphylococci. These species showed high resistance against multi drugs such as Cotrimoxazole, Ampicillin-sulbactam, and Piperacillin-tazobactam. National health policymakers should focus on surveillance programs to control and monitor such trends in antibiotic resistance.

کلیدواژه ها:

Antibiogram ، Antibiotic resistance ، Antibiotic susceptibility ، Iran ، Neonatal Intensive Care Unit