Direct vicinal oxy-azidation of unsaturated carbon-carbon bonds: a facile synthetic route to α-azido ketones

α-Azido carbonyls include compounds that are known to possess wide range of biological activities or are important templates in medicinal chemistry. They are also extremely powerful building blocks for the efficient synthesis of diverse arrays of biologically important N-heterocyclic compounds. In the light of the importance of this family of organic azide compounds a great deal of attention has been given to their synthesis and, in the past years, several methods have been described in the literature allowing for the direct construction of these substances from easily accessible alkene and alkynes by vicinal oxy-azidation reactions. However, no comprehensive review on this chemistry has been published to date. In this light, here we intend to summarize the advances in this attractive field with special attention on mechanistic features of the reactions.

کلیدواژه ها:

vicinal difunctionalization ، oxy-azidation ، organic azides ، α-azido ketones ، Alkenes ، Alkynes