The Effect of Banana (Musa nana Lour.) Peel Extract and Omega-۳ on Biochemical and Histopathological Characteritics in Rat Model of Polycystic Ovary Syndrome

Background: In women of reproductive age, polycystic ovary syndrome (PCOS) is a prevalent endocrine condition. This study assessed the effect of banana (Musa nana Lour.) peel extract and omega-۳ on biochemical and histopathological features in rat model of PCOS.Methods: After PCOS induction, ۵۶ adult female rats were randomly divided into seven groups. In group ۱, healthy rats were given ۲۰ mg/kg/day of normal saline. Group ۲ comprised PCOS rats receiving saline as ۲۰ mg/kg/day. Group ۳ included rats with PCOS receiving ۲۴۰ mg/kg/day omega-۳. Group ۴ consisted of rats with PCOS receiving ۶mL/kg/day of banana peel extract. Group ۵ contained rats with PCOS receiving ۱۲ mL/kg/day banana peel extract. Group ۶ enrolled rats with PCOS taking ۲۴۰ mg/kg/day omega-۳ and ۱۲ mL/kg/day banana peel extract. Group ۷ consisted of rats with PCOS treated with ۲۰۰ mg/kg/day metformin. Serum biochemical parameters and ovarian oxidative stress were evaluated together with histological assessment. The duration of treatment for all groups was ۸ weeks.Results: Glycemic indices, serum triglyceride level, serum testosterone concentration, oxidative stress, and body weight significantly decreased. The ovarian tissue pathology in the animals treated with banana peel extract and omega-۳ in comparison to the PCOS control group showed an improvement (p<۰.۰۵).Conclusion: Omega-۳ supplementation with banana peel extract as an antioxidant may have beneficial effects on biochemical parameters and pathological demonstrations of PCOS.

کلیدواژه ها:

Banana ، Omega ۳ ، Polycystic ovary syndrome ، Histopathology ، Insulin Resistance