Effects of Local beta -adrenergic antagonists on diabetic foot ulcers healing: A systematic Review

Diabetic foot ulcers (DFUs) are chronic and resistant-to-treatment wounds afflicting a considerable portion (۱۹% to ۳۴%) of diabetic patients and account for ۴۰-۷۰% of non-traumatic leg-amputations. Unfortunately, despite enormous investments alongside with wound specialist adherence to the best standard wound care regimens, only ۳۱% of DFUs heal after ۲۰ weeks of treatment. So, urgent need to research for state-of-the-art alternative approaches is needed. Hereon, beta-antagonists as cost-effective and widely-used agents in the treatment of dermatological conditions have been reported to improve wound healing. Therefore, this review conducted to provide a comprehensive summary about the effects of both systemic and topical beta blockers on DFUs healing.

کلیدواژه ها:

beta blocker ، adrenergic beta-antagonist ، diabetic foot ulcer ، chronic wound