The effects of PPARγ agonists on BDNF, NO and apoptosis in the hippocampus area of juvenile hypothyroid rats

The aim of the present study was to evaluate the effect of rosiglitazone (RSG) or pioglitazone (POG) on neuronal apoptosis in the hippocampus of juvenile hypothyroid rats. The animals were divided into four groups: (۱) control, (۲) propylthiouracil (PTU) (A ۰.۰۵% dose in drinking water for ۴۲ days), (۳) PTU-POG and (۴) PTU-RSG. The POG (۲۰ mg/kg) and the RSG (۴ mg/kg) were administered by IP injection. Hippocampal tissues were collected to determine BDNF and NO levels and apoptosis degree. PTU administration decreased slope ۱۰-۹۰%, and amplitude of fEPSP compared to the control group. Injection of RSG or POG increased the slope, slope ۱۰-۹۰%, and amplitude of fEPSP in the PTU-POG or PTU-RSG groups in comparison to the PTU group. TUNEL positive neurons and NO metabolites in the hippocampus of the PTU group were higher than that of the control. RSG or POG increased BDNF content in PTU-POG or PTU-RSG groups. Treatment of the rats by POG or RSG decreased apoptotic neurons and NO metabolites in the hippocampus of PTU-POG or PTU-RSG groups compared to the PTU group. The results of this study revealed that POG or RSG normalized neuronal apoptosis, and improved BDNF content in the hippocampal tissue of juvenile hypothyroid rats.

کلیدواژه ها:

Apoptosis ، BDNF ، Hypothyroid ، Pioglitazone ، Rosiglitazone