Rejuvenation of Ovarian Function Using Adipose-Derived Stem Cells: A Systematic Review of the Pivotal Role of Paracrine Growth Factors in Infertility Treatment

Premature ovarian failure (POF) is defined by the cessation of ovarian activity prior to the age of ۴۰, representing a major factor that leads to infertility in females. Current therapies for this issue frequently have associated restrictions. Research shows that adipose-derived stem cells (ADSCs) are proving to be a hopeful treatment option for premature ovarian failure (POF). Consequently, the objective of this study is to conduct a systematic review of the crucial role of paracrine growth factors in restoring ovarian function through the use of adipose-derived stem cells in infertility treatment. New research shows that the transfer of ADSC, at a suitable dosage of ۵ × ۱۰⁶ cells injected on both sides, markedly enhances ovarian function without any systemic or local adverse effects throughout a ۱۲-month timeframe. This enhancement is validated by a notable reduction in follicle-stimulating hormone (FSH) levels and the return of the menstrual cycle in certain instances. Ultrasound assessments, such as antral follicle count and ovarian volume, further support the progress in ovarian function. The enduring viability of this approach and the alignment of the results with earlier research on chemotherapy patients validate the safety and effectiveness of ADSCs in addressing POF, showcasing their promise for sustained therapeutic strategies. Overall, this systematic review shows that adipose-derived stem cells (ADSCs) have significant potential for treating ovarian insufficiency, and the paracrine mechanism plays an important role in this regard. However, for the application of these findings in a clinical setting, more comprehensive clinical studies with a larger number of participants are needed. Additionally, the precise mechanisms of action of ADSCs and the factors influencing treatment success require further investigation. In summary, this study shows that stem cells derived from adipose tissue can provide a new therapeutic option for infertility caused by ovarian insufficiency.

کلیدواژه ها:

Ovarian insufficiency ، ADSCs ، Infertility