Evaluating the Use of Oral Dydrogesterone for the Prevention of Preterm Birth in High - Risk Pregnancies: A Systematic Review of Clinical Trials

Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality worldwide, particularly in high-risk pregnancies. Oral dydrogesterone, a synthetic progestogen, has shown potential in reducing the risk of preterm labor through its anti-inflammatory and uterine-relaxing effects. Progesterone supplementation, particularly with oral dydrogesterone, has been proposed to prevent PTB and improve pregnancy outcomes in high-risk cases. This systematic review aimed to evaluate the efficacy and safety of oral dydrogesterone in reducing PTB rates and improving neonatal outcomes.

کلیدواژه ها:

Dydrogesterone ، preterm birth ، threatened miscarriage ، preterm labor ، progesterone therapy ، neonatal outcomes