Evaluation of Lipid Peroxidation, Nitric Oxide Metabolites, and Plasma Total Homocysteine Concentration in Patients with Chronic Kidney Disease

Introduction: Numerous factors contribute to the advancement of progressive kidney damage in chronic kidney disease (CKD). Among these, oxidative damage plays a significant role in the progression of CKD. The reactions involving free radicals are recognized as a crucial element that can exacerbate oxidative damage in patients with CKD. However, the precise mechanisms underlying oxidative damage remain incompletely understood. Consequently, this study aimed to explore oxidative and other associated biochemical parameters. Materials and Methods: This case-control study included ۳۸ male and ۲۳ female patients, with mean ages of ۵۸.۹ ± ۱۵.۹ and ۶۲.۱۳ ± ۱۳.۴۳ years, respectively. At the same time, ۴۰ healthy male and ۲۲ healthy female individuals with an average age of ۶۰.۳۳ ± ۱۰.۶۲ and ۵۹.۳ ± ۶.۶۴, respectively, were selected as the control group who had no history of any diseases such as hypertension, diabetes, infection and kidney disease. Research variables including malondialdehyde (MDA), nitric oxide metabolites (nitrite/nitrate), and homocysteine (Hcy) concentration were measured in both case and control groups. Statistical analysis was done according to the obtained results. Results: There was a significant increase in homocysteine concentration in CKD patients compared to the control (P = ۰.۰۰۱). Nitrite and nitrate metabolites exhibited a substantial reduction in patients when compared to the control group (P = ۰.۰۰۱). On the other hand, malondialdehyde (MDA) showed a significant increase in patients compared to controls (P = ۰.۰۱). Conclusion: The findings indicate that homocysteine levels, lipid peroxidation, and alterations in nitric oxide may significantly contribute to the progression of oxidative damage in patients with chronic kidney disease (CKD) and may also influence the disease’s pathogenesis.

کلیدواژه ها:

Chronic kidney failure ، Homocysteine ، Lipid peroxidation ، Nitric oxide ، Oxidative damage ، نارسایی مزمن کلیه ، آسیب اکسیداتیو ، هموسیستئین ، پراکسیداسیون لیپیدی ، نیتریک اکسید