The Role of Autophagy in Cellular Health and Disease

In my thesis, I explore the pivotal role of autophagy in maintaining cellular health and its implications in various diseases. I begin by defining autophagy and tracing its historical significance within cellular biology, highlighting its essential function in cellular homeostasis through the degradation and recycling of components. I delve into the intricate mechanisms of autophagy, detailing its stages and the critical proteins involved, such as mTOR and AMPK, which regulate this process. The thesis further investigates the beneficial aspects of autophagy in health, including its contributions to cellular maintenance, longevity, and potential therapeutic applications. Conversely, I examine autophagy's dual role in disease contexts, specifically in cancer and neurodegenerative disorders, where it can both inhibit and promote disease progression. I conclude by summarizing the key findings and addressing future research directions, emphasizing the need for targeted therapies to effectively modulate autophagy and the ethical considerations surrounding such interventions.

کلیدواژه ها:

Autophagy ، Cellular Health ، Disease ، Therapeutic Applications ، Mechanisms