Synthesis and Characterization of Two Sustained Release Systems of Micro- and Nano-sized Particles for Controlled Release of Atorvastatin for Bone Tissue Engineering Applications

Aims: Using osteoinductive agents in combination with tissue engineering scaffolds is considered as a new approach to bone repair. Recently, statins have attracted great attention among a variety of drugs used in bone repair. In order to achieve a sustained release of Atorvastatin from bone scaffolds, two systems, including nanoniosomes and gelatin microspheres, were synthesized and compared. Materials and Methods: Nanoniosomes and gelatin microspheres were prepared by thin-film hydration and single emulsion technique, respectively. Findings: The prepared systems were characterized for morphology, size, carriers’ preparation efficiency, encapsulation efficiency, and drug loading. Also, release profiles of them were evaluated over a period of one week. The results indicated the formation of relatively spherical niosomes with the diameter of about ۶۵۳.۵۲nm and encapsulation efficiency of ۸۱.۳۴%, and formation of gelatin microspheres with the diameter of about ۳۷.۵μm and the encapsulation efficiency of ۷۸.۹۳%. Conclusion: The results showed that gelatin microspheres had a lower burst release than niosomes, and niosomes had more sustained release than gelatin microspheres after ۲۴hr to ۱ week. Albeit, selection of the optimal system requires cellular studies and also the selection must occur according to the severity of the damage and the rate of repair.

کلیدواژه ها:

Atorvastatin ، Drug Delivery System ، Osteogenesis ، Niosome ، Gelatin Microsphere ، آتورواستاتین ، سامانه انتقال دارو ، استخوان سازی ، نیوزوم ، میکروکرات ژلاتین