Effect of Vigorous Aerobic Training on Serum Levels of Some Inhibitory and Excitatory Factors of Angiogenesis in Women with Type ۲ Diabetes

Aims: Vascular disorder is one of the consequences of diabetes. Physical activity also plays an important role in the improvement of this disorder. Therefore, the aim of this study was to investigate the effect of vigorous aerobic training on serum levels of inhibitory and excitatory factors of Angiogenesis in women with type ۲ diabetes. Materials and Methods: In this quasi-experimental study with pre-test and post-test design that was performed among women with diabetes population in Gorgan in volunteer sampling, ۲۸ women with type ۲ diabetes in Gorgan were selected By … sampling method and were divided into training and control groups (۱۴ individuals each group). Training intervention consisted ۸ weeks of vigorous aerobic exercise (۷۰%-۸۰%) with ۳ times per week. Just before the exercise and ۴۸ hours after that, serum levels of Nitric Oxide (NO), Vascular Endothelial Growth Factor (VEGF), and Endostatin (ES) were evaluated. The data were analyzed by SPSS۲۴ software, using repeated measures ANOVA.. Findings: Eight weeks of aerobic training caused a significant increase in serum levels of NO (p=۰.۰۱۶), VEGF (p=۰.۰۳۶), and an insignificant increase in ES (p=۰.۲۳۷). Also, a significant decrease was observed in fasting blood glucose (p=۰.۰۲۷) and A۱C (p=۰.۰۰۳) compared to the control group. Conclusion: Regular aerobic exercise improves serum levels of angiogenesis-related and metabolic factors in women with type ۲ diabetes.

کلیدواژه ها:

Type ۲ Diabetes ، Nitric Oxide ، Vascular Endothelial Growth Factor ، Endostatin ، دیابت نوع دو ، نیتریک اکساید ، فاکتور رشد اندوتلیال عروقی ، اندواستاتین