Effect of Aerobic Exercise on Renal Angiotensin-II and Angiotensin Type ۱ Receptor Levels in Administered Rats with Nano Zinc Oxide

Aim: Zinc oxide nanoparticles are known as important metal oxide nanoparticles and are used in many medical and biological fields, but concerns are rising due to their potential effects on some organs. The aim of this study was to investigate the effect of aerobic exercise on renal angiotensin-II and angiotensin type ۱ receptor levels in administered Rats with Nano Zinc Oxide. Materials and Methods: In this experimental research, ۳۵ male Wistar rats were randomly divided into control, salin, nano zinc oxide, exercise and exercise plus nano zinc oxide groups. Zinc nitric oxide (۱mg/kg) was injected intraperitoneally, ۵ days a week into exercise and exercise plus nano zinc oxide groups. The exercise program consisted of progressive running on a treadmill (۵ sessions per week for ۴ weeks). Two days after the last application, the rats were euthanized. The kidney tissue is separated and angiotensin-II and angiotensin type ۱ receptor were measured. Data were analyzed by SPSS ۲۰ software using one-way ANOVA and Tukey’s post hoc test. Findings: After ۴ weeks of chronic treatment with nano zinc oxide, the levels of angiotensin-II and angiotensin type ۱ were significantly increased. Exercise significantly reduced renal angiotensin II and angiotensin type ۱ levels. However, these variable levels in exercise plus nano zinc oxide group still were significantly higher than control group (p<۰.۰۵). Conclusion: Aerobic exercise reduces renal angiotensin II and angiotensin type ۱ levels in Administered Rats with nano zinc oxide.

کلیدواژه ها:

Angiotensin II ، Angiotensin Type ۱ ، Exercise Training ، Nanoparticles ، Zinc Oxide ، آنژیوتانسین II ، گیرنده نوع ۱ آنژیوتانسین ، تمرین ورزشی ، نانوذرات ، اکسید روی