The effect of ۴ weeks of endurance exercise on the expression of the muscle Myonectin levels and Insulin resistance in the adult rat

Purpose of the study: Myokines derived from skeletal muscle modulate metabolic, inflammatory, and other processes action. Myonectin, a novel myokine, expression and Circulating its level were tightly regulated by the metabolic state, fasting suppressed and exercise. The aim of this study was to investigate the effect of ۴ weeks of endurance training on gene expression Myonectin muscle activity and plasma insulin resistance, in the male adult rats.Materials and methods: Sixteen Wistar rats (mean weight: ۲۳۰ ± ۱۵ g; age: ۸ weeks) were divided into two groups: (۱) Endurance Training and (۲) Control groups. Animals in exercise groups received ۴-wk endurance training (۵ sessions per week) that included running on a treadmill for ۴۵ minutes and at the same time, the control group did not have any exercise. The Soleus muscle homogenates and the expression of Myonectin genes were measured by Real- time PCR analysis. The enzyme-linked immunosorbent assay (ELISA) method for measuring insulin resistance. The data were analyzed by Independent T Test. Statistical differences were considered significant at P

کلیدواژه ها:

Myonectin ، Insulin resistance ، Endurance exercise ، Adult rat ، مایونکتین ، مقاومت به انسولین ، فعالیت ورزشی استقامتی ، رت بالغ