Effects of High Fat Diet and High Intensity Aerobic Training on Interleukin ۶ Plasma Levels in Rats

Objective: Interleukin ۶ (IL۶) is a pro-inflammatory cytokine that plays an important role in obesity and related metabolic disorders. Also, exercise training has been offered in obesity prevention and immune system improvement. Hence, this study intends to survey the effects of high fat diet and high intensity aerobic training on plasma levels of IL۶ in rats. Methods: We divided ۲۸ male Wistar rats into two control groups with normal (CN) or high fat (CH) diet and two training groups with normal (EN) or high fat (EH) diet. The training groups ran for ۶۰ minutes on a treadmill at ۳۵ m/min for ۵ days/week (۷۵% VO۲ max). After ۸ weeks, we collected blood samples for plasma IL۶ assessment. Two-way ANOVA was used for statistical analysis (P≤۰.۰۵). Results: The high fat diet significantly increased the rats’ weights and plasma IL۶ levels. Performance of ۸ weeks of high intensity aerobic training increased IL۶ levels in the normal diet group and decreased IL۶ levels in the high fat diet group. This change was not significant in the normal diet group. Conclusion: High fat diets probably induced inflammation due to elevated IL۶ levels. High intensity aerobic training for ۸ weeks significantly decreased IL۶ levels.

کلیدواژه ها:

Rat ، High intensity aerobic training ، High fat diet ، Interleukin ۶ ، Obesity ، رژیم غذایی پرچرب ، تمرین هوازی شدید ، اینترلوکین ۶ ، چاقی ، موش صحرایی