Investigating the Effect of Taraxacum officinale Extract on Wistar Rats’ Infertility Induced by Cadmium Chloride

This study was conducted to investigate the efficacy of Taraxacum officinale F.H.Wigg. extract on the infertility of male rats. In this research, we investigated the impacts of T. officinale extract on the infertile cadmium chloride-induced Wistar rats. T. officinale extract was fed to mice daily for ۲۸ days with the help of a gavage needle. Then, all ۴۰ rats were anesthetized with ether and dissected, then epididymis were examined morphologically. Also, we analyzed their right tests for cell line counts and H/E staining and their left testicles were analyzed to evaluate superoxide dismutase (SOD) and malondialdehyde (MDA) enzymes. Our analysis of three sperm quality parameters showed a significant increase in viability, motility and the number of sperm cells in infertile groups treated with ۱۰۰, ۲۰۰, and ۴۰۰ mg/kg T. officinale extract. Our SOD analysis revealed T. officinale extract caused to produce more enzymes in the healthy experimental groups, even compared to the healthy control group. Also, our analysis indicated that increasing the dosage of the T. officinale extract resulted in increasing enzyme production in infertile groups. MDA analyses showed that the healthy experimental groups produced a lower amount of MDA enzyme, which is almost the same level as the healthy control group. Also, due to the usage of T. officinale extract, the level of lipid peroxidation and MDA significantly decreased. In the current study, T. officinale extract can have significant positive impacts on the viability, motility, number of sperms in oxidative stress conditions.

کلیدواژه ها:

Taraxacum officinale ، male fertility ، oxidative stress ، spermatogenesis