A Systematic Review of the Expression Pattern of Long Non-Coding RNAs SNHG۵, SNHG۱۷, and SNHG۲۶ in Human Solid Tumors

Introduction: Small nucleolar RNA host genes (SNHGs) are a class of long non-coding RNAs that have been increasingly associated with various cancers and are emerging as key players in cancer progression.This systematic review aimed to analyze the expression patterns and potential roles of SNHG۵, SNHG۱۷, and SNHG۲۶ in various solid tumors.Methods: A comprehensive literature search was conducted across databases including PubMed, Cochrane, and Google Scholar, to identify relevant studies. Initially retrieved papers were screened based on titles and abstracts for relevance, with exclusion criteria applied to eliminate duplicate publications, case reports, conference abstracts, and irrelevant studies.Results: A total of ۲۱ papers met the criteria for this systematic review, focusing on SNHG۵ (۵ articles), SNHG۱۷ (۷ articles), and SNHG۲۶ (۹ articles). These studies consistently highlighted the upregulation of SNHG۵, SNHG۱۷, and SNHG۲۶ in various cancer types, emphasizing their potential as prognostic and therapeutic targets in solid tumors.Conclusion: The findings suggest a consistent overexpression of SNHG۵, SNHG۱۷, and SNHG۲۶ in cancerous tissues, supporting their potential as prognostic markers in solid tumors. Further investigations should consider the regulatory mechanisms of SNHGs and explore their therapeutic implications in cancer management. This review highlights the importance of understanding the roles of SNHGs in cancer progression and calls for continued research efforts.

کلیدواژه ها:

LncRNA ، SNHG ، Expression ، Tumor