Cytotoxic Activity of Xanthones from Garcinia parvifolia Miq.

Garcinia parvifolia Miq, a Clusiaceae family plant, is a cooking spice and traditional herbal medicine. Xanthones, bioactive compounds, and chemical markers found in abundance in Garcinia plants are known for their cytotoxic activity as promising candidates for cancer therapy. Information on the structure-activity relationship of xanthones against breast cancer (۴T۱) and melanoma cells (B۱۶F۱۰) is limited. This study aims to find the potential of xanthones from G. parvifolia Miq. stem bark against melanoma and breast cancer cells. Three xanthone derivatives, rubraxanthone, α-mangostin, and xanthone I, were isolated from G. parvifolia. The molecular structures of xanthones were determined and focused using ۱D and ۲D NMR spectra. Three xanthones were assayed for breast cancer (۴T۱) and melanoma cells (B۱۶F۱۰). Rubraxanthone exhibited an IC۵۰ value of ۱۰.۹۶ μM, which was moderate activity against ۴T۱ cells; α-mangostin and xanthone I were inactive, and against B۱۶F۱۰ cells; all of the isolated were inactive.

کلیدواژه ها:

Cytotoxic activity ، breast cancer ، Xanthones ، Garcinia parvifolia Miq ، rubraxanthone