Production of Knockout Mice for DYRK۱B, ANRIL, and C۱ORF۱۳۲ Genes Using the CRISPR/Cas۹ System

The CRISPR/Cas system is currently recognized as a highly efficient method for genome editing. The DYRK۱B, ANRIL, and C۱ORF۱۳۲ genes are located in human chromosomal regions ۱۹q۱۳.۲, ۹p۲۱.۳, and ۱q۳۲.۲, respectively. Previous studies have linked these genes to various diseases, including heart disorders, type ۲ diabetes, type ۱ diabetes, and several cancers. To elucidate the functions and molecular mechanisms associated with these genes and their roles in the aforementioned diseases, this study employs the CRISPR/Cas system to generate knockout mouse models for these genes.

کلیدواژه ها:

Knockout ، CRISPR/Cas ، Diabetes ، cancer ، DYRK۱B ، ANRIL ، C۱ORF۱۳۲