Pelvic Exenteration (PE) in Gynaecological cancers: Indications, Complications and Overall Survival (OS) analysis.

Pelvic exenteration (PE) is a surgical procedure that requires an en-bloc excision of lower abdominopelvic structures. Despite its high morbidity, PE is most indicated for treatment of advanced primary or locally recurrent pelvic cancers. We aim to evaluate our experience with PE for patients with gynaecological cancers over ۸ years from January ۲۰۱۱ to ۳۱ December ۲۰۱۹ that were identified through hospital databases. Patient demographic characteristics, indications, surgical characteristics and outcomes were retrospectively assessed. Overall survival (OS) was analysed with Kaplan-Meier method and log rank test. Cox proportional hazards regression was used to model survival outcomes. Twenty- one patients were identified with recurrent cervical, endometrial, ovarian and, or vaginal cancer underwent PE. Local disease recurrence was the most common indication in ۸۰.۹%. The primary tumor origin was the cervix in ۸۰.۹%, followed by endometrial origin ۹.۵%. PE was performed as curative intent in ۶۲% and in ۳۸% as palliative intent. The most common early complication was wound infections and late complications included deep vein thrombosis, lymphocyst and recurrent urinary tract infections. The median survival at ۶ months is ۸۵.۷% and ۱۲ months is ۵۷.۱ %. Our five-year OS was ۵۴.۳ % (۹۵% CI ۳۴.۲, ۷۴.۶). Our case series illustrates pelvic exenteration provides about ۵۴.۳% of ۵-year survival chance in a selected group of patients. The early-and late complications rate are similar to those described historically. Pelvic exenteration results in sustained survival in selected patients and continued efforts must focus on identifying those patients who could potentially benefit most from PE.

کلیدواژه ها:

Pelvic exenteration ، Indications ، Complications ، Overall survival (OS)