Neuroprotective Effect of Allogeneic Biomaterial on Rat Neocortex After Its Intramuscular Injection

Background: Forced physical activity violates all organ and system interactions. Allogeneic biomaterial has been used for many years for regeneration, but its remote exposure has not been studied.Objectives: The aim of this research is the morphological study of experimental animals’ precentral gyrus neocortex under forced physical activity and after intramuscular injection of allogeneic biomaterial. Methods: Male Wistar rats were used for the experiment. The Porsolt test or despair test was used for ۳۰ days. In the main group (n=۱۰), after ۳۰ swimming sessions, allogeneic biomaterial (BMA) was injected intramuscularly. In the control group (n=۱۰), the animals were injected with saline in the same volume. Then, ۵ and ۲۱ days after the injections, a tolerance load test was performed, after which the animals were taken out of the experiment by insufflation of a lethal dose of chloroform vapors. Their brains were removed, and morphological studies were performed.Results: In the experimental group, ۵ days after the BMA injection, the median level of the multiplicity of the tolerant load was significantly higher than that in the control group and remained so in the long term. The neocortex of the control group animals was characterized by the development of pathomorphological changes. After ۲۱ days, these signs persisted. No sign of nervous tissue edema was detected in the early period after the BMA injection. A clear architectonics of the neocortex neurocyte layers were preserved.Conclusion: Allogeneic biomaterial has a positive systemic effect on the organism. Also, neuroprotective and immunomodulating effects have been recorded.

کلیدواژه ها:

allogeneic biomaterial ، cerebral cortex ، forced swimming ، neuroprotection ، rats