The association of gene expressions of MAP۳K۷, NF۲, STK۳ and STK۴ there with Quantum Resonance Magnetic Analyzer (QRMA) in COVID -۱۹ patients

Assessment of some important genes may capability in COVID-۱۹ patients. We investigated mRNA and protein expression of MAP۳K۷, NF۲, STK۳ and STK۴ in virus-infected patients. In addition, we used Quantum Resonance Magnetic Analyzer (QRMA) in order to analyze blood lipids, basic physical quality, lung function and immune system. The Expression of the mRNA level of objective genes was assessed with the SYBR Green Real-time Polymerase Chain Reaction method. The protein level expression of target genes was calculated by Enzyme-linked Immunosorbent Assay. Statistical analyses were accomplished with SPSS software and GraphPad Prism software. The mRNA and protein expressions level in the group of patients decreased significantly compared to healthy individuals. The Arterial oxygen content Paco۲, low-density lipoprotein-C, tonsil immune index and immunoglobulin index were significantly higher than in control. In contrast, the amount of High-density lipoprotein-C, bone marrow index, respiratory immune index and gastrointestinal immune index were significantly lower than in the control. Accordingly, when the expression of genes decreased maybe it can increase the influence of coronavirus. Increasing the amount of the arterial oxygen content Paco۲, low-density lipoprotein-C, tonsil immune index, immunoglobulin index and decreasing the amount of the High-density lipoprotein-C, bone marrow index, respiratory immune index and gastrointestinal immune index can be involved in the effects of coronavirus. Therefore, a deep perception of the relationship between these objective genes and QRMA therewith pathogenesis of COVID-۱۹ infections in a larger population is required.

کلیدواژه ها:

COVID-۱۹ patients ، gene expressions ، Quantum Resonance Magnetic Analyzer ، mRNA ، protein expression ، blood lipids