Roles of miR-۲۱ in the Onset and Advancement of Colorectal Cancer (CRC)

MiR-۲۱ is a critical small regulatory RNA involved in various cellular processes such as cell cycle, apoptosis, migration, and differentiation of stem cells. It is significantly upregulated in CRC cell lines and tissue samples, acting as a biomarker and playing an important role in the pathogenesis of CRC. MiR-۲۱ targets and downregulates tumor suppressor genes such as PDCD۴, which are part of the PI۳K- mTOR pathway. The inverse relationship between miR-۲۱ and PDCD۴ expression highlights the miR-۲۱ role in CRC progression. Research shows that miR-۲۱ is upregulated in human CRC cell lines and tissue samples, correlating with advanced clinical stages, lymph node metastasis, and poor prognosis. This regulation highlights the potential of miR-۲۱ as a biomarker for the early detection of CRC and as a therapeutic target for developing targeted therapies. MiR-۲۱ regulates several CRC-related target genes, highlighting its role in cancer initiation, transformation, invasion, and metastasis. These findings provide valuable insights into miR-۲۱'s role in cancer pathogenesis and its potential clinical applications.

کلیدواژه ها:

Colorectal Cancer ، miR-۲۱ ، miRNA ، Oncogenic ، genetics factor