A Multi-scale Monte Carlo Simulation on Gold Nanoparticle Dose Enhancement for a Lung Tumor Treated with I-۱۲۵ Brachytherapy

It has been shown that the addition of gold nanoparticles in the tumour can improve the treatment gain in radiation therapy. In the present study, the dose enhancement ratio caused by I-۱۲۵ Brachytherapy seeds with the presence of ۳, ۵, and ۷ mg/g gold nanoparticles has been evaluated. The simulations were carried out on both macroscopic and microscopic scales using Geant۴ and Geant۴-DNA Monte Carlo toolkits, respectively. In both simulation scales, increasing the concentration of gold nanoparticles resulted in a dose enhancement of up to nearly ۷۵%. Simulation results were similar at both macroscopic and microscopic scales when gold nanoparticles were physically defined, as opposed to when only tumour and cell densities were increased by the presence of nanoparticles. Direct and indirect DNA damage per primary photon also increased by raising the concentration of gold nanoparticles. In conclusion, the combination of gold nanoparticles with I-۱۲۵ brachytherapy will be a promising approach for the treatment of lung tumours.

کلیدواژه ها:

Brachytherapy ، Lung cancer ، Nanoparticles ، Monte Carlo simulation ، Geant۴