Gene Detection of Some Virulence Factors In Klebsiella Pneumoniae Isolated From UTI

Klebsiella spp. is one of the most common causes of nosocomial infections in the United States, causing ۸% of all nosocomial infections. Out of ۱۶۰; ۲۴ samples show the infection of Klebsiella identified on the basis of DNA isolation and checking with PCR using identified markers like rmpA and iroN. The infection was observed more predominantly in females and immunodeficient persons. The organisms were identified by the. Antibiotic susceptibility was checked for different groups of antibiotics like Cell Wall synthesis inhibitors - Ampicillin-sulbactam, Imipenem, Cefotaxime, Piperacillin. Protein synthesis inhibitors included – Tobramycin, Nitrofurantoin, Tetracycline, Chloramphenicol, and Nalidixic acid, Ciprofloxacin will be used as DNA synthesis inhibitors. The antibiotic resistance was seen to different antibiotics at their specified concentrations. The above obtained data suggest that microorganisms like Klebsiella pneumoniae are deadly pathogens and become more deadly with their capacity of drug resistance so there is a need to find out alternate therapy to eradicate the infection of such organisms.

کلیدواژه ها:

Klebsiella pneumoniae ، UTI ، antibiotic resistance