Antidiabetic activity of Citrullus colocynthis compounds against glycogen phosphorylase using molecular docking

Diabetes is one of the developing diseases in the world that leads to increased blood sugar. Chemical drugs such as metformin, acarbose, etc. are used to treat diabetes, which have side effects. As a result, the desire to replace and use medicinal plants to treat diabetes has increased. Citrullus colocynthis is one of these medicinal plants whose compounds are effective in treating blood sugar. Our approach is to identify the compounds present in this plant and investigate the inhibitory effect of the compounds on the Glycogen phosphorylase protein, one of the proteins involved in diabetes. We use AutoDock Vina software to perform molecular docking and find effective compounds.

کلیدواژه ها:

Diabetes ، Citrullus colocynthis ، AutoDock Vina ، Glycogen-phosphorylase